I forget which episode it was, but I distinctly remember the Thumbs talking about animation and I think it was Jake who brought up the idea of using old animation as the visual direction for a game. (Correct me if I'm wrong.) That conversation came to mind immediately when I saw the trailer for this game on the Indie Games site:
http://www.youtube.com/watch?feature=player_embedded&v=1Gv-rSnZV6U
The article describes it as as puzzle adventure game, and it looks fantastic. Also, +1 for the dude doing the voice over having an accent.
Edit: Just realized I've never figured out how to post a video here, so I just left URL. Derp.