Thought, as a longtime "girl-gamer", that I might throw my two cents in.
My three sisters and I have been "real" gamers ever since the Intellivision days, and we still are. I think it really is a grand misconception that A: most females don't play video games, and B: if they do, they don't like "real" games. I play all kinds of games, from Metal Gear Solid to Resident Evil to Final Fantasy and yes, The Sims... and everything in between.
My personal favorite genre? Survival horror. Hardly what females are stereotyped as enjoying. So yeah, I DO like the Sims 2, but I also like a whole bunch of other stuff more.
Incidentally, I've never noticed that it isn't socially acceptable to be a female gamer, except to- guess who?- some guys. They find out a girl likes video games, and automatically think "oh, how cute, she's just saying that to please me" and try to show her how to use a controller/keyboard/mouse/whatever.
I recommend checking out womengamers.com for some statistics of how many gamers are female (who actually play games, not just buy them for other people).