I used a respec potion on my mid-40's Engineer, and found myself regretting it pretty much immediately. My build is now 'better', but I feel a bit more detached from my character now that I don't have all of those skill points in odd places that don't usually make sense. I'm tempted to spec back into my stupid I-don't-know-where-to-put-any-of-these-points build so that it feels a little more natural.
On the bright side, playing a ranged Embermage after a melee-focused Engineer is a fresh of breath air. The only downside being that I've now leveled my wizard up to Act II, which is a bit too familiar to be appealing to me right now.